News

Our manuscript with the Reck-Peterson, Knapp, Mathea and Dougherty groups on the structure and regulation of LRRK1 is out in NSMB. Here’s the bioRxiv version.
Our manuscript with the Reck-Peterson lab on the regulation of dynein by Lis1 is out in NSMB. Here’s the bioRxiv version.
Our manuscript with the groups of Stefan Knapp and Sebastian Mathea on the first structures of LRRK2 bound to type-1 and type-2 kinase inhibitors is out in bioRxiv.
Our manuscript with the groups of Dong Wang, Nan Hao, and Shisheng Li, on the interactions of Elf1 and Rad26 with lesion-arrested Pol II is out in bioRxiv.
Amalia is awarded an NSF Postgraduate Fellowship.
Our manuscript with the Reck-Peterson lab on the structures of human dynein bound to Lis1 is out in eLIFE. And here’s the bioRxiv version.

2023

Our manuscript with the Reck-Peterson, Daugherty, and Knapp labs on the structures of LRRK1 and its mechanisms of autoinhibition and activation is out in bioRxiv.
Our manuscript with the Reck-Peterson lab on the structural basis for LRRK2’s binding to microtubules is out in NSMB. And here’s the bioRxiv version.
Our manuscript with the Reck-Peterson lab on the structures of human dynein bound to Lis1 is out in bioRxiv.
Our manuscript with the Reck-Peterson lab on a new Lis1-mediated intermediate in the activation of dynein is out in bioRxiv.
Mar Matyszewski leaves the lab to become the new Director of the UC San Diego Cryo-EM Facility.
Robert Fagiewicz (Postdoctoral Fellow) joins the lab.
Kendrick Nguyen and Amalia Villagran (Graduate Students, Chem & Biochem) join the lab.
Our paper with the Reck-Peterson lab on the structural basis of dynein regulation by Lis1 is out in eLIFE. And here’s the bioRxiv version.

Our review with Sam Reck-Peterson on the structural biology of LRRK2 is out in Movement Disorders.
Marta Sanz Murillo (Postdoctoral Fellow) joins the lab.
Jaime Alegrio Louro (Postdoctoral Fellow) joins the lab.
Reta successfully defended her thesis and became Dr. Reta.

ASAP funded our proposal to work on LRRK2 and Parkinson’s Disease in collaboration with the Reck-Peterson, Villa, Knapp and Stengel labs. [Here’s the announcement from UCSD.]

Our paper with the Reck-Peterson, Villa and Knapp labs on the structure of LRRK2 and its mechanism of binding to microtubules is out in Nature and here is the bioRxiv version.
Colin started his new job at the Genomics Institute of the Novartis Research Foundation here in La Jolla.
Colin successfully defended his thesis and became Dr. Colin.
Our paper with the Reck-Peterson lab on the regulation of dynein by Lis1 is out in Nature Cell Biology. And here is the bioRxiv version.
Our paper with the Dominguez lab on the structure of a core RSC complex bound to a nucleosome is out in NSMB. And here is the bioRxiv version.

Rick starts his own lab at the University of North Carolina, Chapel Hill.
Mariusz Matyszewski (Postdoctoral Fellow) joins the lab.
Rachael Barry leaves to start as an Assistant Teaching Professor at UC Irvine.
Our paper with the Hollopeter Lab on the regulation of the AP2 complex is out in eLIFE. And here is the bioRxiv version.
Darren Nguyen (Undergraduate, Physics) joins the lab.
Janice is awarded a Damon Runyon Postdoctoral Fellowship
Indrajit starts his own lab at IISER-Mohali
Our manuscript on using streptavidin affinity grids to solve a 3.1Å structure of RNA Polymerase II is out in JSB. And here is the bioRxiv version.
David is awarded a Postdoctoral Research Fellowship from the A.P.Giannini Foundation.
Yu Xuan Lin (Undergraduate, Chem & Biochem) joins the lab.

Adam Weir (Postdoctoral Fellow) leaves to start his new job at the National Cryo-Electron Microscopy Facility at NCI.

Colin is awarded a Pre-Doctoral Fellowship from the Center for Trans-scale Structural Biology and Biophysics at UC San Diego.
Janice Raimer (Postdoctoral Fellow) joins the lab.
David Snead (Postdoctoral Fellow) joins the lab as a joint postdoc with the Reck-Peterson lab.
Our paper with the Cianfrocco lab on cryo-EM data processing and model building in the cloud is out in JSB. And here is the BioRxiv version.

Aji Palar (Undergraduate, Chem & Biochem) joins the lab.
Aji gets a UC Scholars fellowship to spend the summer doing research in the lab.
Reta is awarded an NSF Postgraduate Fellowship.
Mike starts his own lab at the Life Sciences Institute of the University of Michigan, Ann Arbor.
Our paper with the Reck-Peterson lab on the two opposing modes of dynein regulation by Lis1 is out in Cell. And here is the BioRxiv version.
Our paper with the Wang lab on the structural basis for eukaryotic transcription-coupled DNA repair initiation is out in Nature.

Rick Baker (Postdoctoral Fellow) joins the lab.
Colin Deniston (Graduate Student, Chem & Biochem) joins the lab.
Reta Sarsam (Graduate Student, Chem & Biochem) becomes a joint graduate student with the Joseph lab.
Rick is awarded a Damon Runyon Postdoctoral Fellowship.
Rachael is awarded an IRACDA Postdoctoral Fellowship.
Colin is accepted into the Molecular Biophysics Training Grant.

We are moving to UCSD!
Our paper on cryo-EM data processing in the Cloud is out in eLIFE. And here is the BioRxiv version.
John successfully defends his thesis and becomes Dr. John.
Rogelio successfully defends his thesis and becomes Dr. Rogelio.
Rachael Barry (Postdoctoral Fellow) joins the lab.
Our review with the Reck-Peterson lab on the regulation of cytoplasmic dynein is out in Annual Reviews of Cell and Developmental Biology.

Our paper with the Reck-Peterson lab on how Lis1 blocks dynein's mechanochemical cycle is out in eLIFE.
Adam Weir (Postdoctoral Fellow) joins the lab.
Indrajit Lahiri (Postdoctoral Fellow) joins the lab.
The R01 on dynein is funded.
Vu successfully defends his thesis and becomes Dr. Vu.
Peter Kraft (Harvard undergraduate) joins the lab.

Our paper with the Wu lab on the molecular architecture of SWR1 is out in Cell.
Mike is awarded a Damon Runyon Postdoctoral Fellowship.
Mike Cianfrocco (Postdoctoral Fellow) joins the lab.

Our paper with the Reck-Peterson labon the analysis of tug-of-war in motor protein ensembles using DNA origami in out in Science.
Bret successfully defends his thesis and becomes Dr. Bret.
Our paper with the Reck-Peterson lab on the structural basis of microtubule binding and release by dynein is out in Science. See the highlights on the MCB website and the Harvard Gazette.
Our paper with the Reck-Peterson lab on the regulation of dynein by Lis1 is out in Cell.
Kat is awarded a Charles King Postdoctoral Fellowship.

Kat Toropova (Postdoctoral Fellow) joins the lab.
Our paper on the validation of OTR with a biological test sample is out in J.Struct.Biol.

The R01 on chromatin remodeling is funded.
Four lab members receive NSF Postgraduate Fellowships! Congrats to Vu Nguyen, Brandy Pappas, Koning Shen and John Srouji.
Rogelio Hernandez-Lopez (Graduate Student, CCB) joins the lab.

Bret Redwine (Graduate Student, BBS), Vu Nguyen (Graduate Student, MCO), John Srouji (Graduate Students, MCO) and Brandy Pappas (Graduate Student, Biophysics) join the lab.
Andres receives an Alfred P. Sloan Research Fellowship.